Biennial Meetings

Scientific Program

Wednesday, September 17, 2008
1100 - 1900	Registration Desk Open
1400 - 1600	ISACB Executive Council Meeting
1400 - 1800	Poster Set Up
1800 - 1900	Welcome Reception
1900 -	Wine Tutorial - Separate subscription
Thursday, September 18, 2008
0700 - 1700	Registration
0715 - 1215	Exhibitor/Poster Set Up (Exhibit Hall)
0730 - 0750	Presidential Welcome

0750	Keynote Speaker - Dr. Jean-Paul Broustet, Professor Emeritus University of Bordeaux Bordeaux, France Wine and cardiovascular prevention: Facts and fiction
0830	Innovative Cardiovascular Biomaterials Co-chairs: L Bordenave, J Hubbell
1.1 0830 - 0855	Invited Speaker Functional cardiovascular biomaterials L Bordenave University of Bordeaux Bordeaux, France
1.2 0855 - 0920	Invited Speaker Extracellular matrices as cardiovascular biomaterials J Hubbell Ecole Polytechnique Federale de Lausanne Lausanne, Switzerland
1.3 0920 - 0940	Vascular endothelial and smooth muscle cells on nanostructured materials containing ligands for cell adhesion receptors L Bacakova, E Filova, J Chlupac, E Brynda, T Riedel, D Kubies, L Machova, V Proks, F Rypacek Institute of Physiology Academy of Sciences Czech Republic
1.4 0940 - 0950	Effect of surface topology and polymer properties on drug release profiles J Puskas and R Hoerr The University of Akron Akron, Ohio and Nanocopoeia Inc., St Paul, Minnesota, USA
1.5 0950 - 1000	Micro-CT to quantify functional neovascularisation into porous polyurethane C Schmidt, M Beck, D Bezuidenhout, P Zilla, and N Davies University of Cape Town, Cape Town, South Africa and Medtronic, Minneapolis, Minnesota
1000 - 1030	COFFEE BREAK
1.6 1030 - 1055	Invited Speaker Control of the cardiovascular microenvironment using novel biomaterials B Ratner University of Washington Seattle, Washington, USA
1.7 1055 - 1120	Invited Speaker Microengineered cardiovascular hydrogel biomaterials A Khademohosseini Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
1.8 1120 - 1130	Transient inflammatory response and artery remodeling following endoluminal paving of porcine femoral arteries: Our experience with PEG-based bioabsorbable hydrogels K Messier, J Trudel, D Borkowski, P Him, M Kalstad, A Shah, S Tunev, M Slepian, C Wilcox and A Coury Genzyme Corporation, Framingham, Massachusetts; Medtronic Cardiovascular, Santa Rosa, California and University of Arizona, Tucson, Arizona, USA
1.9 1130 - 1140	Polysaccharide-based porous scaffolds for cell delivery into the infarcted heart D Letourneur, O Gournay, C Le Visage, J Baptiste Michel, J Flanders, N Mougenot, R Isnard, S Hatem and F Norol INSERM Paris, France
1140 - 1200	Panel Discussion of Invited Speakers
1200	Buffet Lunch - Manned Poster Session
1400	Developmental Cardiovascular Biology (Collaborative with Soc. CV Pathology) Co-chairs: FJ Schoen, G Thiene
2.1 1400 - 1425	Invited Speaker Blood vessel formation and remodeling K Hirschi Baylor College of Medicine, Houston, Texas, USA
2.2 1425 - 1450	Invited Speaker Novel aspects of cardiac development and cell fate AC Gittenberger-de Groot Dept. of Anatomy and Embryology Leiden University Medical Center Leiden, The Netherlands
2.3 1450 - 1500	Notch signaling promotes macrophage activation M Aikawa Harvard Medical School, Brigham and Women's Hospital Boston, Massachusetts, USA
2.4 1500 - 1510	The proliferation and invasion of SMCs increases EC sprout formation and persistence within fibrin matrices A Ucuzian, D Bufalino and H Greisler Loyola University Medical Center, Stritch School of Medicine and Department of Surgery; Department of Cell Biology, Neurobiology, & Anatomy, Loyola University Medical Center Maywood, Illinois, USA
2.5 1510 - 1520	YOUNG INVESTIGATOR AWARD RECIPIENT MCP-1 is an essential mediator in tissue engineered blood vessel development J Roh, S Jay, L Devine, M Brennan, T Yi, E Snyder, M Saltzman, J Pober, T Kyriakides, and C Breuer **Presented by C. Breuer Yale University School of Medicine New Haven, Connecticut, USA
1520 - 1550	COFFEE BREAK
2.6 1150 - 1615	Invited Speaker Bicuspid aortic valve: a paradigm for the role of aberrant developmental pathobiology in congenital cardiac anomalies G Thiene University of Padua Medical School Padua, Italy
2.7 1615 - 1640	Invited Speaker Signaling events in heart valve development HS Baldwin Vanderbilt University Nashville, Tennessee, USA
2.8 1640 - 1650	Growth and differentiation dynamics in cardiovascular tissue neogenesis A Lebacq, G De Visscher, L Mesure, I Vranken, and W Flameng Catholic University Leuven (KULeuven) Leuven, Belgium
2.9 1650 - 1700	TRAVEL AWARD WINNER Altered shear stress induces aortic valve leaflet inflammation in a bone morphogenic protein-4 and transforming growth factor-β1-dependent mechanism P Sucosky, K Balachandran, A E, H Jo, and A Yoganathan Georgia Institute of Technology and Emory University Atlanta, Georgia, USA
1700 - 1720	Panel Discussion of Invited Speakers
1900	Welcome Reception – Hotel d’ville
	Travel by Tram - Directions at Registration Desk
Friday, September 19, 2008
0700	Registration Open
0730	Poster Viewing
0800	Cardiovascular Mechano-Pathophysiology and Tissue Remodeling Co-chairs: D Vorp, G Garcia-Cardena
3.1 0800 - 0825	Invited Speaker Molecular mechanisms of mechanotransduction in atheroprotection G Garcia-Cardena Brigham & Women’s Hospital Boston, Massachusetts, USA
3.2 0825 - 0850	Invited Speaker Abdominal aortic aneurysms: Evolving concepts in pathobiology and biomechanics D Vorp University of Pittsburgh Pittsburgh, Pennsylvania, USA
3.3 0850 - 0900	Effects of different types and magnitudes of flow on EC B Sumpio Yale University New Haven, Connecticut, USA
3.4 0900 - 0910	Fluid force induced Smad2 activation in human aortic endothelial cells K Rinker, R Shepherd, J Irwin, S Tehranian, and S Kos University of Calgary Calgary, AB, Canada
3.5 0910 - 0920	CYP 1A1 and 1B1 upregulation under shear stress in cultured endothelial cells S Eskin, D Conway, and L McIntire Georgia Institute of Technology Atlanta, Georgia, USA
0920 - 0950	COFFEE BREAK
3.6 0950 - 1015	Invited Speaker Genetic Analysis of Flow Induced Vascular Remodeling Vyacheslav Korshunov University of Rochester Rochester, New York, USA
3.7 1015 - 1040	Invited Speaker Molecular Imaging in Cardiac and Vascular Disease: Opportunities and Challenges E. Aikawa Massachusetts General Hospital Harvard Medical School Charlestown, Massachusetts, USA
3.8 1040 - 1050	TRAVEL AWARD WINNER Mechanical stimulation differentially controls proliferation, morphology, and vascular gene and protein expression in mesenchymal progenitor cells T Maul, D Chew, A Nieponice, and D Vorp University of Pittsburgh Pittsburgh, Pennsylvania, USA
3.9 1050 - 1100	TRAVEL AWARD WINNER Cyclic stretch and heart rate regulate matrix metalloproteinases and their inhibitors in aortic valves K Balachandran, P Sucosky, H Jo and A Yoganathan Georgia Institute of Technology Atlanta, Georgia, USA
3.10 1100 - 1110	Induction of vascular cell differentiation by fluid-mechanical forces in embryonic stem cells J Ando, N Shimizu and K Yamamoto The University of Tokyo Tokyo, Japan
1110 - 1130	Panel Discussion of Invited Speakers
1140	Luncheon Buffet – Concurrent Company Presentations Laboratoire Perouse, Bornel, France – M. Thomas Walter, R&D Manager Bose ElectroForce, Eden Prairie, Minnesota - Sandy Williams and Leto Mejia Miltenyi Biotec GmbH, Bergisch Gladbach, Germany - Petra Hennemann, Project Manager Medical Development
1300	Engineering cell-based regeneration of cardiovascular tissues Co-chairs: S Hoerstrup, P Menasche
4.1 1300 - 1325	Invited Speaker Cell sheet engineering approaches T Okano Tokyo Women’s Medical Center Tokyo, Japan
4.2 1325 - 1350	Invited Speaker Heart valve and conduit engineering: Is growth possible? S Hoerstrup University Hospital Zurich, Switzerland
4.3 1350 - 1400	TRAVEL AWARD WINNER A novel system for enhanced endothelial cell transplantation via local growth factor delivery S Jay, B Shepherd, J Pober, and W M Saltzman Yale University New Haven, Connecticut, USA
4.4 1400 - 1410	Cellular origin of tissue-engineered vascular grafts grown in the peritoneal cavity J Campbell, J Mooney, B Rolfe and G Campbell The University of Queensland Brisbane, Queensland, Australia
1410 - 1430	COFFEE BREAK
4.5 1430 - 1455	Invited Speaker Cell-based therapy for cardiac repair P Menasche Hospital European George Pompidou Paris, France
4.6 1455 - 1520	Invited Speaker Engineered myocardium W Zimmerman University Medical Center Hamburg-Eppendorf, Germany
4.7 1520 - 1530	Combined therapy of endothelial progenitor, mesenchymal and unpurified bone marrow stem cells in a coated muscle patch after myocardial infarction in a murine model L Barandon, L Leroux, D Lionel, C Thierry and C Duplaa INSERM PESSAC, France
4.8 1530 - 1540	Tissue-engineered human embryonic extracellular matrix for cardiovascular applications R. Kellar, F Zeigler and G Naughton Histogen, Inc. San Diego, California, USA
4.9 1540 - 1550	Encapsulation of osteoprogenitor and endothelial cell co-cultures for tissue engineering application M Grellier, S Bidarra, R Bareille, J Fricain, P Granja, M Barbosa and J Am INSERM, Bordeaux, France; INEB, Porto, France and INEB, Porto, Portugal
1550-1610	Panel Discussion of Invited Speakers
1700	Depart for Chateau Dinner Bus Departures from Cite Mondiale at 1700, 1730 and 1745
Saturday, September 20, 2008
700	Registration Desk Open
0900	ISACB Members Business Meeting
0930	Challenges in Clinical Translation of Innovative Cardiovascular Biology, Devices and Therapies (e.g. animal models, clinical trials, regulatory issues, reimbursement) Co-chairs: D Williams, JJ Rosen
5.1 0930 - 0955	Invited Speaker Challenges in clinical translation of cardiovascular tissue engineering and regenerative therapies FJ Schoen Brigham & Women’s Hospital, Harvard Medical School Boston, Massachusetts, USA
5.2 0955 - 1020	Invited Speaker Overcoming barriers to innovation: Special challenges for cardiovascular technologies JJ Rosen Boston University School of Management Boston, Massachusetts, USA
5.3 1020 - 1030	High-resolution MRI enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis M Aikawa Harvard Medical School, Brigham and Women's Hospital Boston, Massachusetts, USA
5.10 1030 - 1040	Multiphoton Flow Cytometry to Guide Cellular Transplantation for Cardiovascular Disease B Ogle, D Buschke and K Eliceiri University of Wisconsin-Madison Madison, Wisconsin, USA
5.4 1040 - 1050	TRAVEL AWARD WINNER In vitro perfused microvessel networks C Chang and J Hoying Cardiovascular Innovation Institute Louisville, Kentucky, USA
5.5 1100 - 1110	YOUNG INVESTIGATOR AWARD WINNER The angiogenic effects of CXCL12 variants and the expressions of CXCL12 variants and CXCR4 in human critical limb ischaemia T Ho, S Xu, P Leoni, C Black, D Abraham, G Hamilton, and D Baker The Royal Free and University College Medical School London, United Kingdom
5.6 1110 - 1120	CBAS-heparinized ePTFE vascular prostheses for peripheral arterial disease: Development to clinical treatment J Fisher, R Thomson, D Kanjickal, and P Begovac W. L. Gore & Associates, Inc. Flagstaff, Arizona, USA
5.7 1120 - 1130	Clinical in-vitro endothelialization: 15 years experience P Zilla University of Cape Town Cape Town, South Africa
5.8 1130 - 1155	Invited Speaker Regulatory challenges in evolving cardiovascular therapies K Hellman The Hellman Group, LLC Clarksburg, Maryland, USA
5.9 1155 - 1220	Invited Speaker European regulatory approaches in tissue engineering and regenerative medicine D Williams University of Liverpool Liverpool, United Kingdom
1220 - 1250	Panel Discussion of Invited Speakers
1300	Dismissal

Biennial Meetings

Scientific Program

Wednesday, September 17, 2008

Thursday, September 18, 2008

Keynote Speaker - Dr. Jean-Paul Broustet, Professor Emeritus

Innovative Cardiovascular Biomaterials

Developmental Cardiovascular Biology (Collaborative with Soc. CV Pathology)

Friday, September 19, 2008

Cardiovascular Mechano-Pathophysiology and Tissue Remodeling

Engineering cell-based regeneration of cardiovascular tissues

Saturday, September 20, 2008

Challenges in Clinical Translation of Innovative Cardiovascular Biology, Devices and Therapies (e.g. animal models, clinical trials, regulatory issues, reimbursement)