Poster Sessions

Novel Molecular Approaches in Cardiovascular Research

P1
Applications of Human Tissue-Engineered Blood Vessel Models to Study the Effects of Shed Membrane Microparticles from T-Lymphocytes on Vascular Function

J M Bourget, M Pricci, H Robitaille, C Porro, R Soleti, F Auger, C Martinez, R Andriantsitohaina,
L Germain

Université Laval - LOEX, Québec, QC, Canada; INSERM 771, CNRS UMR 6214 and Université d'Angers, Faculté de Médecine, Angers, France

P2
Three Dimensional Modeling of Pathologic Vascular Smooth Muscle Cell Behavior: the Role of Focal Adhesion Kinase

L Brewster, A Ucuzian, E Brey, A Gassman, A Samarel, H Greisler

Loyola University Medical Center, Maywood, IL; Illinois Institute of Technology, Chicago, IL; Edward J. Hines VA Hospital, Hines, IL , USA

Cell-based Repair/Regeneration

P3
Role of the Rho/Rho Kinase Pathway in Determining the Morphology and Viability of Cardiac Fibroblasts Following Mechanical Loading

L A Clark, M H Yacoub, A H Chester

Imperial College London, Harefield, United Kingdom

P4
Osteopontin is critical for estrogen-stimulated endothelial repair

A P Gadeau, L L Shang Leen, C Filipe, F Robbesyn, D Daret, C Allieres, C Desgranges, J F Arnal

INSERM U828, Pessac, France; INSERM U858, Toulouse, France

P5
In Vitro Tissue Engineering of Decellularized Leaflets with Human Mesenchymal Stem Cells: The Influence of Matrix Fibre Distribution on Cell Engraftment

L Iop, V Renier, F Naso, A Gandaglia, M. Piccoli, M Marchini, P DeCoppi, M Spina, S Sartore, G Gerosa

University of Padova, Padova, Italy; University of Udine, Udine, Italy; Great Ormond Street Hospital, London, United Kingdom

P6
Design of Artificial Microtissues to Regenerate the Heart Muscle

J M Kelm, G Fischer, C Zuppinger, V Djonov, E Ehler, S P Hoerstrup

University of Zurich, Zurich, Switzerland; University of Bern, Bern, Switzerland; University of Fribourg, Fribourg, Switzerland; King's College London, London, United Kingdom; University Hospital of Zurich, Zurich, Switzerland

P7
Tissue-Engineered Blood Vessel for Vascular Substitution: Signal Transduction under Shear Stress in Endothelial Cells lying on the Tissue-Engineered Matrix

M Rémy, J F Oligny, R Daculsi, P Fernandez, R Bareille, L Bordenave, F Auger, L Germain

INSERM U577, Bordeaux, France and Laboratire d'Organogénèse Expérimentale, Hôpital du Saint-Sacrement du CHA, Laval University, Sainte-Foy, QC, Canada

P8
Osteopontin mediates the estradiol effect on endothelium regrowth by increasing the ability of bone marrow-derived cells to adhere to endothelial cells

F Robbesyn, L L Shang Leen, C Duplàa, P Dufourcq, I Belloc, C Desgranges, A P Gadeau

Inserm, Pessac, France

P61
Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells

JM Melero-Martin, ME De Obaldia, SY Kang, ZA Khan, L Yuan, P Oettgen, J Bischoff

Children's Hospital Boston, Boston, MA and Beth Israel Deaconess Medical Center, Boston, MA

Tissue Engineering – Cell Sourcing (includes stem cells and other cell sourcing options)

P9
Role of Polyelectrolyte Films on Endothelial Progenitor Cells Differentiation

N Berthelemy, H Kerdjoudj, P Lacolley, J F Stoltz, P Schaaf, J C Voegel, P Menu

Laboratoire de mécanique et ingénierie cellulaire et tissulaire, LEMTA-UMR CNRS 7563, Nancy, France; Laboratoire rigidité, fibrose et risques cardiovasculaires, INSERM U684, Nancy, France; Institut Charles Sadron UPR 22 CNRS, INSERM U 595, Strasbourg, France; Laboratoire Biomatériaux: Processus biologiques et biophysisques aux interfaces

P10
Vascular basement membrane molecules and perivascular cells in co-cultures of human outgrowth endothelial cells and primary osteoblasts

S Fuchs, E Dohle, B Pavic, C Kirkpatrick

Johannes Gutenberg University, Mainz, Germany

P11
Enhanced Cardiac-Specific Differentiation of Mouse Embryonic Stem Cells via Electrical Stimulation

P I Lelkes, P R Bidez III, Y Wei

Drexel University, Philadelphia, PA, USA

P12
Endothelial cell response to mechanical forces induced by a rotating wall bioreactor

Y Missirlis, S Dermenoudis
University of Patras, Patras, Greece

P13
Capillary Sprouting and Angiogenesis by smart Self-inducing Biomimetic Matrices

U Ripamonti, P W Richter, R Nilen, M E Thomas, L Renton

Bone Research Unit, Medical Research Council/University of the Witwatersrand Johannesburg, Johannesburg, South Africa and Materials Science and Manufacturing Technology, Council for Scientific and Industrial Research, Pretoria, South Africa

P14
Restoring the Induction of Bone Formation by Recombinant Human Transforming Growth Factor-beta3 with rectus abdominis Responding Stem Cells in the Non-Human Primate Papio ursinus

U Ripamonti, C Ferretti, J Teare, L Renton

MDent, Spec Max-Facial Surg, PhD (Med), Bone Research Unit, Medical Research Council/University of the Witwatersrand Johannesburg, Johannesburg, South Africa

P15
Development of a Tissue-Engineered Vascular Graft in Rat and Pig Models

L Soletti, A Nieponice, B Gharaibeh, N Gupta, J Guan, Y Hong, J Huard, W Wagner, D Vorp

University of Pittsburgh, Pittsburgh, PA, USA

P16
Human Peripheral Blood Progenitor Derived Endothelial Cells in Response to Shear Stress Conditions: Sensitivity at mRNA Level

N Thébaud, R Bareille, C Bourget, M Rémy, S Fuchs, L Bordenave

INSERM U577, Bordeaux, F-33076 France; INSERM U577, Université Victor Segalen Bordeaux 2, F-33076, France; Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, D-55101 Mainz, Germany

P64
Could Intraluminal Mesenchymal Stem-Cells (MSCs) Seeding Improve Synthetic Biodegradable Vascular Graft Healing?

BH Walpoth, a Rungatscher, D Kong, JC Tille, B Nottelet, M Moeller, R Gurny A Kalangos

Tissue Engineering – Intelligent Matrices, Scaffolds

P17
Signal Transduction in Transendothelial Migration of Melanomas Using a Human Tissue-Engineered Blood Vessel (TEBV)

C Basoni, M C Fiola, D Lacroix, F A Auger

Laboratoire d'Organogenèse Expérimentale, Québec, QC, Canada

P18
ECM Gel and ECM-derived Laminin Strongly Attenuate Granulocyte Adhesion and Activation on Decellularized Porcine Heart Valve Tissue in Vitro

F Bastian, M Stelzmueller, E Eichmair, M Kasimir, P Simon, G Weigel

Medical University of Vienna, Vienna, Austria

P19
A new platform for cell adhesion

R Berat, M Remy-Zolghadry, C Gounou, L Bordenave, A Brisson

Université Bordeaux 1, Talence, France and Université Bordeaux 2, Bordeaux, France

P20
Poly(ethylene terephtalate) Surface Functionalization by RGD Peptide Grafting with Controlled Densities

C Chollet, C Chanseau, M Rémy, R Bareille, B Brouillaud, L Bordenave, M C Durrieu

INSERM U577, Bordeaux, France

P21
A sustained increase in scaffold neovascularisation after VEGF stimulation is dosage dependent

N Davies, S Dobner, D Bezuidenhout, C Schmidt, M Beck, A Zisch, P Zilla
Presented by D. Bezuidenhout

Cardiovascular Research Unit, University of Cape Town, Cape Town, South Africa; Medtronic Inc, Minneapolis, MN; Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland

P22
Modulation of Vascular Cell Mobility for Tissue Engineering of Cardiovascular Implants - a 3-D Approach

M H Fittkau, M Ramsperger-Gleixner, T Fischlein

Dept. for Cardiac Surgery, Klinikum Nuremberg, Nuremberg, Germany and Dept. for Cardiac Surgery, University of Erlangen, Erlangen, Germany

P23
Synthetic Peptides for Heart Valve Tissue Engineering: Smooth Muscle Cells Adhesion Tests

A Gandaglia, R Huerta Cantillo, F Naso, M Spina, R Danesin, M Dettin

University of Padova, Padova, Italy

P24
Angiogenic Potential of Human Macrophages on Electrospun Bioresorbable Vascular Grafts

K Garg, D C Smith, P Madhurantakam, S Sell, G L Bowlin

Virginia Commonwealth University, Richmond, VA, USA

P25
Vascular Tissue Engineering with Infra-Red (1064 nm) Laser Printing : Preliminary Results

F Guillemot, M Rémy, A Souquet, M Faucon, R Bareille, J Lopez, L Bordenave, P Fernandez

INSERM U577, Bordeaux, F-33076 France; Université Victor Segalen Bordeaux 2, F-33076, France; ALPHANOV Centre Technologique Optique et Laser, Talence, F-33405, France

P26
Rabbit carotid bypassed by cryopreserved human umbilical arteries treated with polyelectrolyte multilayer films.

H Kerdjoudj, N Berthelemy, S Rickenbach, J F Stoltz, P Schaaf, J C Voegel, Patrick Menu

UHP, Vandoeuvre les Nancy, France; INSERM, Strasbourg, France; CNRS, Strasbourg, France

P27
Co-electrospun PLGA, Gelatin and Elastin Blend Nanofibers as Potential Scaffolds for Vascular Grafts

P I Lelkes, J Han, M Li, X Chen

Drexel University, Philadelphia, PA, USA; Chinese Academy of Sciences, Changchun, China

P28
Endothelial Cells Adhesion on PET Membrane Grafted with RGD Peptidomimetics

J Marchand-Brynaert, V Rerat, S Devouge, G Dive, A Cordi, G Tucker, R Bareille, M Durrieu, L Bordenave

Université catholique de Louvain, Louvain-la-Neuve, Belgium; Université de Liège, Sart-Tilman, Liège, Belgium; Insitut de Recherches Servier, Suresnes, France; Université Bordeaux 2, INSERM U577, Bordeaux, France

P29
Multilayered Film and Endothelial Cells: Two Complementary Compounds Necessary to the Autologous Endothelialization of ePTFE Synthetic Vascular Prostheses

V Moby, C Boura, J C Voegel, J F Stolz, P Menu

Cellular and Tissular Engineering Lab, Vandoeuvre, France and INSERM U595, Strasbourg, France

P30
Evaluation of a New Scaffold Material for Heart Valve Tissue Engineering: Non-woven PLDLA Meshes coated with Electrospun PLDLA Nanofibers

D Schmidt, C Mariani, A Puolakka, M Rissanen, T Deichmann, S Jockenhoevel, S P Hoerstrup

University Hospital Zürich, Zürich, Switzerland; Department of Materials Science, Tampere University of Technology, Tampere, Finland; Dipl-Ing, Institute for Textile Techniques, RWTH Aachen University, Aachen, Germany; Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany and Department of Surgical Research, University Zurich, Zürich, Switzerland

P31
In Vitro Immune Responses to Electrospun Polydioxanone and Elastin Bioresorbable Vascular Graft Materials

M J Smith, D C Smith, K L White, Jr., G L Bowlin

Virginia Commonwealth University, Richmond, VA and Virginia Commonwealth University, Philip Morris USA, Richmond, VA , USA

P32
Inhibition of Platelet Activation Strongly Reduces Granulocyte Adhesion and Activation on Decellularized Porcine Heart Valve Tissue

M E Stelzmueller, M T Kasimir, F Bastian, E Eichmair, G Kolroser, P Simon, G Weigel

Medical University of Vienna, Vienna, Austria

P33
Mechanical behavior of polyelectrolyte multilayers on polyethylene terephtalate vascular prosthese

D Vautier, S Rinckenbach, B Durand, N Chakfé, JC Voegel

Faculté de Chirurgie Dentaire, INSERM U595, Strasbourg, France; Service de Chirurgie Vasculaire, CHU Besançon, Besançon, France; Laboratoire de Physique et Mécanique Textil/EGBM, Mulhouse, France; Service de Chirurgie Vasculaire, Hôpitaux Universitaires de Strasbourg, INSERM U595, Strasbourg, France

P34
Biodegradable Small Calibre Polydioxanone-based Vascular Prostheses: Potential as Coronary Bypass Grafts

B H Walpoth, M Cikirikcioglu, D Mugnai, J C Tille, A Kalangos, G Bowlin

University Hospital, Geneva 14, Switzerland and Virginia Commonwealth University, Richmond, VA, USA

P35
Interest of Multiphoton and Second Harmonic Generation for blood vessel imaging

E Werkmeister, H Kerdjouj, J F Stoltz, D Dumas

Laboratoire de Mécanique et Ingénierie Cellulaire et Tissulaire, VANDOEUVRE-les-NANCY, France

P36
In Vitro Evaluation of Monocyte Interactions with Electrospun Bioresorbable Vascular Graft Materials: Tissue Factor Expression

P Wolfe, P Madhurantakam, K Garg, S Sell, M Beckman, G Bowlin

Virginia Commonwealth University, Richmond, VA, USA

P62
Electrospun MCP-1 Delivery Systems: Creating Cellular Homing Scaffolds to Stimulate In Situ Angiogenesis and Tissue Regeneration

GL Bowlin, MJ Smith, PS Wolfe, KL White, Jr.

Virginia Commonwealth University, Richmond, VA, USA

P65
Drug Eluting Degradable Synthetic Vascular Prosthesis: Friend or Foe?

BH Walpoth, F Innocente, B Nottelet, E Pektok, J-C Tille, RA Kalangos, R Gurney, M Moeller

Departments of Cardiovascular Surgery and Pathology, University Hospital Geneva, Department of Pharmaceutics & Biopharmaceutics EPGL, Geneva Switzerland

Innovative Cardiovascular Biomaterials

P37
Crosslinkable, Thermoplastic Polyurethanes for Cardiovascular Prostheses

D Bezuidenhout, J P Theron, J Knoetze, R D Sanderson, R Hunter, K Mequanint, P Zilla

University of Cape Town, Observatory, South Africa; University of Stellenbosch, Stellenbosch, South Africa; University of Cape Town, Rondebosch, South Africa; University of Western Ontario, London, ON, Canada

P38
Mechanical and Biocompatible Properties of Collagen and Photocrosslinkable Hyaluronic Acid Interpenetrating Networks

M Brigham, A Bendali, A Bick, S Jinno, J Burdick, A Khademhosseini, Ph.D

Harvard Medical School-MIT & Brigham & Women's Hospital, Cambridge, MA; Brigham & Women's Hosp, Harvard Medical School, Cambridge, MA and Dept. of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA

P39
Nitric Oxide Releasing Novel Nanocomposite Material for Cardiovascular Applications

A de Mel, B Ramesh, A Darbyshire, G Hamilton, A Seifalian

Biomaterials & Tissue Engineering Centre, Academic Division of Surgical & Interventional Sciences, University College London and Royal Free Hampstead NHS Trust Hospital, London, United Kingdom

P40
Design and Testing an Origami Stent Graft with Embedded Scaffold and Nanocomposite Polyurethane Cover

J Eaton-Evans, Z You, A Darbyshire, R Bakhshi, G Hamilton, A Seifalian

University of Oxford, Oxford, United Kingdom and University College London, London, United Kingdom

P41
Evaluation of a New Membrane Vascular Access Graft in an Ovine Model

G Edwards, E Fenech, R C Howlett

University of Melbourne, Werribee, Victoria, Australia and University of New South Wales, Sydney, Australia

P42
In situ Bioengineering of Arterial Vein Grafts

M S El-Kurdi, B C Morelli, Y Hong, W R Wagner, D A Vorp

University of Pittsburgh, Pittsburgh, PA, USA

P43
LCL Grafts: Innovative Small Caliber Vascular Grafts

P I Lelkes, A Perets, P Uttayarat, M Li, R Composto, R J Levy

Drexel University, Philadelphia, PA; University of Pennsylvania, Philadelphia, PA; Childrens' Hospital of Pennsylvania, Philadelphia, PA, USA

P44
Proliferation of Aortic Adventitial Fibroblasts on Three Novel Polyisobutylene (PIB)-Based Thermoplastic Elastomers (TPEs)

L G Munoz-Robledo, S P Schmidt, J E Puskas, M Evancho-Chapman

The University of Akron, Akron, OH and Summa Health System, Akron, OH, USA

P45
Development of Nanocomposite Polymer for Cardiovascular Devices

A Darbyshire, H Salacinski, G Hamilton, A Seifalian

University College London, London, United Kingdom and Royal Free Hampstead NHS Trust Hospital, London, United Kingdom

P46
Tri-Layered Electrospun Polycaprolactone - Elastin - Collagen Small Diameter Grafts: Compliant Tubes for Reproducing Native Vessel Mechanics

S Sell, M McClure, B Walpoth, G Bowlin

Virginia Commonwealth University, Richmond, VA and University Hospital, Geneva, Switzerland

Cardiovascular Pathology

P47
Sarcomere cytoskeleton remodelling in diseased heart

I Agarkova, R Schoenauer, P Bennet, A Fellew, T Pedrazzini, S Hoerstrup

University Hospital of Zurich, Zurich, Switzerland

P48
External Vein Support with constrictive Nitinol Meshes suppresses neointima formation in non-human Primates

P Zilla, L Moodley, P Human, M Black, J Scherman, M Wolf, T Franz

University of Cape Town (UCT), Cape Town, South Africa and Medtronic Inc, Minneapolis, MN, USA

Heart Valves

P49
Novel Designed Bioreactor for Tissue-Engineered Heart Valves (TEHV)

A Gandaglia, A Bagno, G Gerosa

University of Padova, Padova, Italy

P50
Correction of Acute Functional Mitral Regurgitation: Development of a Dynamic Epicardial Device

B Gleyzolle, E Monnet

Colorado State University, Fort Collins, CO, USA

P51
Species-dependent Variability of the Host Response to Bioprosthetic Tissue

P Human, H IIsley, e duPlessis, B Sc. Hons, M Black, P Zilla

University of Cape Town, Cape Town, South Africa

P52
Novel expansible ring for conservative aortic valve surgery: an in vivo study of biocompatibility and function

E Lansac, N Bulman-Flemming, I Di Centa, A Ranga, F Raoux, A Paolitto, D Letourneur, A Meddahi-Pellé

Inserm U698, Paris, France; CoroNéo Inc, Montreal, QC, Canada; Service de chirurgie vasculaire, CHU Ambroise Paré, Paris, France; CHU Saint Antoine, Paris, France; Inserm U698 Bioingenierie Cardio-vasculaire, Paris, France

P53
Non syndromic mitral valve prolapse: evidence of Tgf-beta pathway activation in surgically resected leaflets

S Rizzo, E Carturan, G Gerosa, A Paolin, G Thiene, C Basso

University of Padova, Padova, Italy

P54
Antifibrotic Coatings For Rapidly Exchangeable Bioprosthetic Valve

I Vesely

ValveXchange Inc., Denver, CO, USA

P63
A new calcification resistance, biostable, biocompatible POSS-nanocomposite polymer for developing new generation of heart valves

A S Mofrad, H Ghanbari, AG Kidane, G Burriesci, B Ramesh, H Mirzadeh, PP Bonhoeffer, M Edirisenghe, G Hamilton and AM Seifalian

Amirkabir University of Technology, Tehran, Iran, Islamic Republic; University College London (UCL), London, United Kingdom; Great Ormond Street Hospital for Children, London, United Kingdom; Royal Free Hampstead NHS Trust Hospital, London, United Kingdom

P66
On the micro-architecture of human bicuspid aortic heart valves

M Sacks, E Joyce, R Gorman J Gorman

University of Pittsburgh, Pittsburgh, PA and University of Pennsylvania, Philadelphia, PA

P67 TRAVEL AWARD WINNER
Computational and Experimental Investigations into the Mechanisms of Calcification in the Aortic Valve

E Weinberg, MRK Mofrad

Massachusetts Institute of Technology, Cambridge, MA, and University of California Berkeley, Berkeley, CA, USA

Challenges in clinical Translation of Innovative Cardiovascular Biology, Devices and Therapies

P55
Computational Study of Knitted Nitinol Meshes for the Prospective Use as External Vein Reinforcement

T Franz, Ha van der Merwe, P Zilla, D Bezuidenhout, B Daya Reddy

Cardiovascular Research Unit, University of Cape Town, Observatory, South Africa and Centre for Research in Computational and Applied Mechanics, University of Cape Town, Rondebosch, South Africa

P56
Simvastatin Release from a Perivascular Polymeric Controlled Drug Delivery System

A Krishnan, S T Lopina, M Evancho-Chapman, S P Schmidt, D Donovan

The University of Akron, Akron, OH and Summa Health System, Akron, OH, USA

P57
Can the Vineberg procedure improve blood supply of the muscle flap during dynamic cardiomyoplasty? A pilot study.

E Monnet, M Guadagnoli, Jc Chachques

Colorado State University, Fort Collins, CO, USA and Hospital Georges Pompidou, Paris, France

Inflammatory Processes in Cardiovascular Disease and Treatment

P58
Molecular Mechanisms of Cardiovascular Calcification in Chronic Renal Disease

E Aikawa

Massachusetts General Hospital, Charlestown, MA, USA

P59
Gene Expression Changes in Human Monocytes Induced by Transmigration across Activated Endothelial Cells

L V McIntire, M R Williams, S G Eskin

Georgia Institute of Technology, Atlanta, GA, USA

P60
WITHDRAWN